Brigham’s extensive history of achievement in Translational Medicine. 2016 The American Heart Association’s “One Brave Idea” award, a $75 million pledge to end coronary heart disease, is given to Dr. Calum MacRae, TA Strategic Advisor and BWH Chief of Cardiovascular Medicine. This marks the largest research award ever given to one investigator’s team. 2016 The Building for Transformative Medicine opens its doors to patients. A hub for state-of-the-art labs, outpatient clinical space and advanced imaging facilities, the building brings together leading clinicians and scientists to collaborate on and advance care for patients suffering from a range of diseases, such as Alzheimer’s disease, Parkinson’s disease and rheumatoid arthritis. 2015 Geneticist Stephen J. Elledge, PhD, is awarded the 2015 Albert Lasker Basic Medical Research Award for laying a foundation for understanding how cells detect and repair DNA damage. 2011 Opening of the Advanced Multimodality Image Guided Operating (AMIGO) suite, a one-of-a kind, state-of-the-art medical and surgical research environment that houses a complete array of advanced imaging equipment and interventional surgical systems. 2005 BWH publishes significant findings from the TIMI trials. One study found that statin drugs’ ability to combat levels of C-reactive protein (CRP) in one’s blood is just as important as the drugs’ role in reducing cholesterol. 1992 Researchers discover that a protein (amyloid beta) thought to be an early, causative feature of Alzheimer’s disease is also present in healthy individuals, and that patients with Alzheimer’s produce too much of this protein or cannot break it down properly. 1989 BWH, through the Physicians Health Study, is the first to prove that aspirin can prevent first heart attacks. 1986 Researchers establish that methotrexate, previously used exclusively as an anti-cancer drug, is effective in treating severe rheumatoid arthritis. 1984 TIMI (thrombolysis in myocardial infarction) trials are launched. This series of 24 trials, 8 of which are ongoing, has revolutionized the care of heart-attack patients. 1980 Three of Boston’s oldest and most prestigious Harvard Medical School teaching hospitals – the Peter Bent Brigham Hospital, the Robert Breck Brigham Hospital, and the Boston Hospital for Women – merge to form Brigham and Women’s Hospital. 1954 Dr. Joseph Murray performs the first successful organ transplant, moving a kidney between identical twins. 1949 Dr. Carl Walter invents the blood bag at Peter Bent Brigham, where he begins building one of the world’s first blood banks. 1923 The world’s first successful operation on human heart valves is performed by Dr. Elliott Cutler at the Peter Bent Brigham Hospital.